Evidence That Links Loss of Cyclo-Oxygenase-2 With Increased Asymmetric Dimethylarginine: Novel Explanation of Cardiovascular Side Effects Associated With Anti-inflammatory Drugs Running title: Ahmetaj-Shala et al.; Renal COX-2 and regulation of ADMA and LNMMA

Cardiothoracic Pharmacology, Vascular Biology, National Heart and Lung Institute, Imperial College, London, United Kingdom; The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, United Kingdom; King Fahad Cardiac Center of King Saud University, Riyadh, Saudi Arabia; MRC Clinical Sciences, Imperial College London, Nitric Oxide Signalling Group, Hammersmith Hospital, DuCane Road, London, United Kingdom; School of Life and Medical Sciences, University of Hertfordshire, College Lane, Hatfield, United Kingdom; Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Theodor Stern Kai 7, Frankfurt, Germany *contributed equally to this study and their names appear in alphabetical order **contributed equally to this study and their names appear in alphabetical order